The alkaloid of Physostigma – slows action of heart and increases arterial tension; in ciliary spasm and spasmodic ASTIGMATISM due to irregular action of ciliary muscles; blepharo-spasms; PUPILS CONTRACTED. Twitching of lids, soreness of eyeballs, blurring of vision AFTER USING EYES, pains around eyes and head. Used locally to contract the pupil. ESERINE contracts the pupils dilated by ATROPINE, but not those dilated by GELSEMIUM. Internally 6X.