Chininum arsenicosum

Natural History.
      Arsenite of Quinine. (C20H24N2O2) 3H3 As O4 2H2O. Trituration or solution.

Clinical.
      Angina pectoris.
      Asthma.
      Bright’s disease.
      Diarrhoea.
      Diphtheria.
      Epilepsy.
      Gastralgia.
      Hectic fever.
      Hemicrania.
      Intermittent fever.
      Keratitis.
      Ophthalmia.
      Scarlatina.
      Sore-throat, malignant.
      Spinal irritation.
      Syphilis.
      Tobacco, effects of.
      Tuberculosis.

Characteristics.
      The Arsenite of Quinine combines many of the properties of its components, but having been proved it can be treated as a separate individuality.
      The periodicity is intensified, and this is especially noted in the neuralgias.
      An irritable mood precedes the headache, which is worse by mental and bodily exercise.
      The gastralgia of Chin-a. is pressure in solar plexus with tender spine just at back of it.
      Nausea and vomiting are followed by sleep.
      Bonino (H.R., iv.210), who gave it a prolonged proving, found the symptoms worse at rest, in the morning, and when the stomach was empty.
      They were better by motion (vertigo), and by eating (gastralgia).
      The chief effects were manifested on the stomach, solar plexus, ligaments and skin.
      According to him it corresponds to tobacco intoxication and its effects, indigestion from unripe fruits, gastralgia from coarse food or ill-baked bread, chronic rheumatism of joints without swelling, tertiary syphilis of periosteum, colic from incarcerated flatus, intermittent fever with predominating chills, little thirst and continuous almost convulsive yawning, effects of severe and depressing influences on the mind, to convalescence from long-lasting sickness.
      The circulation was slow, and limbs relaxed.
      Weakness, prostration, and disinclination for mental exertion were marked in several provers.

Relations.
      Compare: Apis (diphtheria), Aethusa (sleep after vomiting), Cact. (constricting sensations).

Causation.
      Tobacco.

Mind.
      Dislike of mental occupation in spite of clear-headed lightness about head and feeling of exhilaration.
      Memory impaired.
      Anxiety
      Child sits up in lamenting.
      Irritable mood precedes headache.

Head.
      Sudden attacks of vertigo, worse by looking up.
      Severe darting, tortuous pains, running up into head and preventing sleep.
      Head full as if it would burst.
      On sitting down, head seems to be covered with an iron cap.
      Hemicrania (left) from fright, flickering before left eye and lachrymation, ringing in ears, pain tearing, boring.
      Penetrating pain in region of left temple.
      Dull, heavy headache, frontal and occipital, in cerebellum, worse from slightest motion.

Eyes.
      Intense photophobia and orbicular spasm gushing hot tears, ulcers attacking each eye, worse from midnight to three AM. (Keratitis.)
      Flickering before left eye, with pain and lachrymation. (Hemicrania.)

Ears.
      Ringing in ears like bells, with congestion towards head.
      Noise in ears and dulness of hearing.

Nose.
      Profuse coryza better erect position and out of doors.
      Postnasal catarrh worse left side.
      Copious epistaxis.

Face.
      Trembling of facial muscles, especially orbicularis palpebrum (immediately).
      Dull pain in left temporal region at articulation of lower jaw.
      Face pale, sallow bloated.

Mouth.
      Tongue thickly furred, appetite bad.
      Yellow, slimy coating on tongue, with bitter taste.
      Fetid breath.
      Dryness in roof of mouth, gnawing and nausea.
      Metallic bitter taste, without changing taste of victuals.

Throat.
      Throat feels sore and raw, worse coughing and sneezing.
      Diphtheria.

Stomach.
      Appetite gone.
      Violent thirst for cold water.
      Desire for sweets.
      Empty sensation.
      Hiccough and belching, followed by urging to stool.
      Sudden, indescribable general nausea, with flying heat and waning strength, especially of lower limbs.
      Nausea and vomiting followed by sleep.
      Eggs or fish cause painless diarrhoea at once.
      Gnawing and nausea as before vomiting as at beginning of tobacco-poisoning.
      Pain in stomach as if it had contracted itself round an uneven stone.
      Disturbed in night by severe pain in stomach as if is were pressed against spinal column, better by eating, for a few moments, repeated several mornings.
      Contracting gastralgia, as if pushed up, better only for a moment by tasteless eructations.

Abdomen.
      Pain in epigastrium as from foul stomach.
      Pain as from flatus wedged into flexure of colon.
      Aching around navel and in ilium.
      In evening severe colicky pains better by pressure.

Stool and Anus.
      Violent urging to stool, evacuated in prolonged rush till bowel empty, stool thin, brown, painless.
      Diarrhoea, morning hardly had time to dress, brown, liquid with jelly-like lumps: pain in left iliac region, quite severe when walking.
      Towards morning, frequent, bad-smelling flatus.
      Stool pappy, watery, fetid.
      Stool, fecal, with mucus and blood, preceded and followed by tenesmus.
      Stool hard, voided with difficulty, aided by pressing finger on coccyx.
      Could eat no breakfast, but took some dinner, and immediately thereafter great urging to stool, which was watery and blackish, some pain in hypogastrium.

Urinary Organs.
      Urine scanty, frequent urging.
      Urine increased, urging tiresome.

Male Sexual Organs.
      A peculiar burning ache about sphincter vesicae and throughout urethra.

Respiratory Organs.
      Breathing unsatisfactory, wants more air than he can take into his lungs.
      Respiration very free, as if thorax were hollow.
      Suffocative attacks beginning in morning and lasting till noon, better sitting bent forward at open window, worse every other position.
      Senile subacute bronchial catarrh with periodical fever, generally worse at night.

Chest.
      Severe stitching pains in chest, later in precordia, worse on inspiration.
      Asthmatic breathing on ascending.
      Tightening sensation in mediastinum, in front at left of breast-bone-bone.
      Peculiar pain, dull with pressure, as if caused by flatulence, base of left Chest, coming and going rapidly and frequently repeated.

Heart.
      Angina pectoris.
      Palpitation on leaning against back.
      Sensation as if heart had stopped.
      Heart began to tremble, with a rumbling noise, I was unable to distinguish the pulsation (lasted one hour).
      Slow pulse.
      Left intercostal neuralgia as if torn with hot tongs.

Back.
      Pain in muscles between left shoulder and neck, as if sprained, on rising from sleep, 4 p-m.
      Back feels weak as after a long journey.
      Pressure in solar plexus (usually only felt after eating tough meat or hard nuts, of which I had not partaken) extended toward the back, when it changed to a pinching sensation, spine painfully sensitive to touch at this point.

Upper Limbs.
      Pain in left wrist, stiffness of left arm.
      Pain of fatigue in right wrist.
      Burning pain as in periosteum of left elbow.
      Annoying feeling of fatigue in right shoulder, as if humerus were torn out of its socket.
      Sore, tired aching in joints, bones and muscles, in left biceps for some hours.

Lower Limbs.
      Dull pain in right temporal region, at articulation of jaw and right hip.
      Pain in right astragali-tarsal joint as if bones drawn in opposite directions, better walking.
      Pressure on tuberosity of tibia, which is somewhat swollen.
      Pain in right knee as from a fall.
      Cramp in calf.
      Pains back of right thigh and in calf.
      Numbness of legs after hardly having lain down.
      Weakness of lower limbs.

Generalities.
      In different parts of body burning fluttering beats, as from electricity.
      Stiffness of all bones, even while walking.
      Burning pains deep in joints.
      Burning pains as in periosteum.
      Nervous restlessness, unable to remain in the house.
      While walking, dizziness and collapse.
      Desire to lie down.
      Complete relaxation of muscles as from tobacco-poisoning.

Skin.
      Gooseflesh, especially of lower extremities.
      Periodical furuncles, which relieve the head.
      Burning, erysipelatous redness and violent itching worse by warmth better by cold.

Sleep.
      Night full of visions, heavy sleep till morning.
      Nervous restlessness, anxious dreams.
      Sleep frequently interrupted.

Fever.
      General chill and cold.
      After the feverish cough in the chill, no reaction of warmth.
      Flying heat with nausea.
      Cold, clammy sweat.