Cascara sagrada

Natural History.
      Rhamnus Purshiana. (California.) N. O. Rhamnacae. Extract of bark.

Clinical.
      Constipation.
      Rheumatism.

Characteristics.
      I mention this well-known purgative because it has been found empirically curative in cases of subacute and chronic rheumatism with constipation.
      Pathogenetic effects on patients taking it for constipation have been recorded: Vomiting, severe griping, hemorrhage, in one case temporary insanity (from a home-made decoction of the bark).
      In two cases choleraic symptoms were produced.
      Only material doses have been used.